Efficacy of single‐agent immunosuppressive regimens in a murine model of vascularized composite allotransplantation
نویسندگان
چکیده
منابع مشابه
Facial Vascularized Composite Tissue Allotransplantation
Reconstruction of severe composite defects of the face is challenging for reconstructive surgeons. Despite several reconstructive techniques, the functional and aesthetic results of these patients are not acceptable. As a major organ, face, has an utmost importance in daily life. The specific characteristics of face require not a reconstruction, but a replace with same tissue. With the evolutio...
متن کاملMouse Models of Experimental Vascularized Composite Allotransplantation
The clinical practice of vascularized composite allotransplantation (VCA) has been limited by the potential side effects of chronic immunosuppression. Studies using rodent models have been useful for dissecting mechanisms underlying immunological events induced by VCA and for developing protocols such as mixed chimerism for tolerance induction. Mouse models of VCA have great advantages over rat...
متن کاملCurrent status of vascularized composite tissue allotransplantation
Vascularized composite tissue allotransplantation (VCA) offers treatment options of complex functional deficiencies that cannot be repaired with conventional reconstructive methods. VCAs consist of blocks of functional units comprising different tissue types such as skin, bone, muscle, nerves, blood vessels, tendons, ligaments and others, and are thus substantially different from the compositio...
متن کاملSplit Rejection in Vascularized Composite Allotransplantation
INTRODUCTION Graft monitoring following vascularized composite allotransplantation (VCA) relies primarily on serial skin biopsy. However, given that VCA comprised multiple tissue types, skin biopsy may not accurately reflect rejection in other transplanted tissue. METHODS A review of the literature on episodes of both acute and chronic rejection following VCA was completed. Special attention ...
متن کاملMesenchymal Stem Cells as Immunomodulators in a Vascularized Composite Allotransplantation
Vascularized composite allotransplantations (VCAs) are not routinely performed for tissue reconstruction because of the potentially harmful adverse effects associated with lifelong administration of immunosuppressive agents. Researchers have been eagerly seeking alternative methods that circumvent the long-term use of immunosuppressants. Mesenchymal stem cells (MSCs) show promise as an immunomo...
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ژورنال
عنوان ژورنال: Transplant International
سال: 2020
ISSN: 0934-0874,1432-2277
DOI: 10.1111/tri.13618